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Article

Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy.

Collegium antropologicum - 1 Mar 2013

Sporis Davor, Bozina Nada, Basić Silvio, Lovrić Mila, Babić Tomislav, Susak Ivana, Marković Ivana

Abstract excerpt

Despite advances in antiepileptic drug (AED) therapy, about one-third of patients with epilepsy are resistant to drug treatment. Functional impact of polymorphisms in drug-efflux transporter genes may contribute to multidrug resistance theory. Studies on ABCB1 gene gave contradictory results and available data suggest that this polymorphism may not directly cause altered P-glycoprotein (Pgp) transport activity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23697249

Genes

ABCC2
ABCB1

Variants

Provenance

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Lack of association between polymorphism in ABCC2 gene and response to antiepileptic drug treatment in Croatian patients with epilepsy.PMID 23697249Read ↗

Absence of a general association between ABCB1 genetic variants and response to antiepileptic drugs in epilepsy patients.Semantic proximity Read ↗

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Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy.Semantic proximity Read ↗

Polymorphism in drug transporter gene ABCB1 is associated with drug resistance in Pakistani epilepsy patients.Semantic proximity Read ↗

The ABCC2 c.-24C>T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis.Semantic proximity Read ↗

Polymorphisms Affecting the Response to Novel Antiepileptic Drugs.Semantic proximity Read ↗

A systematic review and meta-analysis of the role of ABCC2 variants on drug response in patients with epilepsy.Semantic proximity Read ↗

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.Semantic proximity Read ↗

Impact of ABCC2 genotype on antiepileptic drug response in Caucasian patients with childhood epilepsy.Semantic proximity Read ↗

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