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Article

Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients.

Epileptic disorders : international epilepsy journal with videotape - 1 Mar 2011

Haerian Batoul Sadat, Lim Kheng Seang, Tan Hui Jan, Mohamed Elsa Hanifa Mejia, Tan Chong Tin, Raymond Azman Ali, Wong Chee Piau, Wong Sau Wei, Omar Haslyna, Roslan Harun, Mohamed Zahurin

Abstract excerpt

Over-expression of P-glycoprotein, encoded by the ABCB1 gene, is proposed to be involved in resistance to antiepileptic drugs in about 30% of patients with epilepsy. Here, we investigated the possible association between ABCB1 polymorphisms and sodium valproate (VPA) treatment in Malaysian epilepsy patients. Genotypes were assessed in 249 drug-resistant and 256 drug-responsive Malaysian patients for C1236T,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21388909
DOI: 10.1684/epd.2011.0419

Genes

ABCB1

Provenance

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Association between ABCB1 polymorphism and response to sodium valproate treatment in Malaysian epilepsy patients.PMID 21388909Read ↗

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