Article
Lack of association between ABCB1, ABCG2, and ABCC2 genetic polymorphisms and multidrug resistance in partial epilepsy.
Epilepsy research - 1 Mar 2009
Kim Dong Wook, Lee Sang Kun, Chu Kon, Jang In-Jin, Yu Kyung-Sang, Cho Joo-Youn, Kim Seon-Jeong
Abstract excerpt
ATP-binding cassette (ABC) transporters participate in drug disposition and response in various conditions, and many polymorphisms in ABC transporter genes have been recognized in association with altered transporter functions of various drugs. Studies on epilepsy have focused on the C3435T polymorphism of the ABCB1 gene, but other ABC transporters are also thought to be involved in the transport of antiepileptic...
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