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Article

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy.

Molecular biology reports - 25 Jan 2024

Rashid Haroon Ur, Ullah Shakir, Carr Daniel F, Khattak Muhammad Ijaz Khan, Asad Muhammad Imran, Rehman Mujeeb Ur, Tipu Muhammad Khalid

Abstract excerpt

BACKGROUND: Epilepsy is a common neurological disease but around 30% of patients fail to respond to antiepileptic drug (AED) treatment. Genetic variation of the ATP-binding cassette subfamily B, member 1 (ABCB1) gene, a drug efflux transporter may infer treatment resistance by decreasing gastrointestinal absorption and preventing AED entry into the brain. This study examined the impact of ABCB1 genetic variants...

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Source

Identifiers

PMID: 38270743
DOI: 10.1007/s11033-023-09061-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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