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Article

Lack of association between ABCB1 gene polymorphisms and pharmacoresistant epilepsy: an analysis in a western Chinese pediatric population.

Brain research - 19 May 2011

Dong Lin, Luo Rong, Tong Yu, Cai Xiaotang, Mao Meng, Yu Dan

Abstract excerpt

OBJECTIVE: The genetic polymorphisms of the ABCB1 (ATP-binding cassette B1) gene encoding P-glycoprotein have been proposed to be associated with pharmacoresistance phenotype in epilepsy patients. P-glycoprotein, a transmembrane transporter, works as an efflux pump by limiting antiepileptic drugs across the blood brain barrier, with correspondingly lowering drug concentrations in epileptogenic loci. In this...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Source

Identifiers

PMID: 21420937
DOI: 10.1016/j.brainres.2011.03.028

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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