Article
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.
PLoS genetics - 27 Jan 2011
Festen Eleonora A M, Goyette Philippe, Green Todd, Boucher Gabrielle, Beauchamp Claudine, Trynka Gosia, Dubois Patrick C, Lagacé Caroline, Stokkers Pieter C F, Hommes Daan W, Barisani Donatella, Palmieri Orazio, Annese Vito, van Heel David A, Weersma Rinse K, Daly Mark J, Wijmenga Cisca, Rioux John D
Abstract excerpt
Crohn's disease (CD) and celiac disease (CelD) are chronic intestinal inflammatory diseases, involving genetic and environmental factors in their pathogenesis. The two diseases can co-occur within families, and studies suggest that CelD patients have a higher risk to develop CD than the general population. These observations suggest that CD and CelD may share common genetic risk loci. Two such shared loci,...
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