Article
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
PLoS genetics - 1 Feb 2011
Zhernakova Alexandra, Stahl Eli A, Trynka Gosia, Raychaudhuri Soumya, Festen Eleanora A, Franke Lude, Westra Harm-Jan, Fehrmann Rudolf S N, Kurreeman Fina A S, Thomson Brian, Gupta Namrata, Romanos Jihane, McManus Ross, Ryan Anthony W, Turner Graham, Brouwer Elisabeth, Posthumus Marcel D, Remmers Elaine F, Tucci Francesca, Toes Rene, Grandone Elvira, Mazzilli Maria Cristina, Rybak Anna, Cukrowska Bozena, Coenen Marieke J H, Radstake Timothy R D J, van Riel Piet L C M, Li Yonghong, de Bakker Paul I W, Gregersen Peter K, Worthington Jane, Siminovitch Katherine A, Klareskog Lars, Huizinga Tom W J, Wijmenga Cisca, Plenge Robert M
Abstract excerpt
Epidemiology and candidate gene studies indicate a shared genetic basis for celiac disease (CD) and rheumatoid arthritis (RA), but the extent of this sharing has not been systematically explored. Previous studies demonstrate that 6 of the established non-HLA CD and RA risk loci (out of 26 loci for each disease) are shared between both diseases. We hypothesized that there are additional shared risk alleles and...
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