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Article

Deep resequencing of 131 Crohn's disease associated genes in pooled DNA confirmed three reported variants and identified eight novel variants.

Gut - 1 May 2016

Hong Sung Noh, Park Changho, Park Soo Jung, Lee Chang Kyun, Ye Byong Duk, Kim You Sun, Lee Seungbok, Chae Jeesoo, Kim Jong-Il, Kim Young-Ho

Abstract excerpt

OBJECTIVE: Genome wide association studies (GWAS) and meta-analyses for Crohn's disease (CD) have not fully explained the heritability of CD, suggesting that additional loci are yet to be found and that the known loci may contain high effect rare risk variants that have thus far gone undetected by GWAS. While the cost of deep sequencing remains too high to analyse many samples, targeted sequencing of pooled DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25731871
DOI: 10.1136/gutjnl-2014-308617

Genes

BTNL2
CARD9
DNAH12
NFKBIA
STAT3
TNFSF15
TNFSF8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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