Article
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
American journal of human genetics - 6 Apr 2012
Ellinghaus David, Ellinghaus Eva, Nair Rajan P, Stuart Philip E, Esko Tõnu, Metspalu Andres, Debrus Sophie, Raelson John V, Tejasvi Trilokraj, Belouchi Majid, West Sarah L, Barker Jonathan N, Kõks Sulev, Kingo Külli, Balschun Tobias, Palmieri Orazio, Annese Vito, Gieger Christian, Wichmann H Erich, Kabesch Michael, Trembath Richard C, Mathew Christopher G, Abecasis Gonçalo R, Weidinger Stephan, Nikolaus Susanna, Schreiber Stefan, Elder James T, Weichenthal Michael, Nothnagel Michael, Franke Andre
Abstract excerpt
Psoriasis (PS) and Crohn disease (CD) have been shown to be epidemiologically, pathologically, and therapeutically connected, but little is known about their shared genetic causes. We performed meta-analyses of five published genome-wide association studies on PS (2,529 cases and 4,955 controls) and CD (2,142 cases and 5,505 controls), followed up 20 loci that showed strongest evidence for shared disease...
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