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Identification of shared loci associated with both Crohn's disease and leprosy in East Asians.

Human molecular genetics - 10 Nov 2022

Jung Seulgi, Park Dohoon, Lee Ho-Su, Kim Yongjae, Baek Jiwon, Hwang Sung Wook, Park Sang Hyoung, Yang Suk-Kyun, Ye Byong Duk, Han Buhm, Sun Yonghu, Liu Hong, Zhang Furen, Liu Jianjun, Song Kyuyoung

Abstract excerpt

Genome-wide association studies (GWAS) of Crohn's disease (CD) in European and leprosy in Chinese population have shown that CD and leprosy share genetic risk loci. As these shared loci were identified through cross-comparisons across different ethnic populations, we hypothesized that meta-analysis of GWAS on CD and leprosy in East Asian populations would increase power to identify additional shared loci. We...

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PMID: 35512355
DOI: 10.1093/hmg/ddac101

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