Article
Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects.
Human molecular genetics - 15 May 2010
Wang Kai, Baldassano Robert, Zhang Haitao, Qu Hui-Qi, Imielinski Marcin, Kugathasan Subra, Annese Vito, Dubinsky Marla, Rotter Jerome I, Russell Richard K, Bradfield Jonathan P, Sleiman Patrick M A, Glessner Joseph T, Walters Thomas, Hou Cuiping, Kim Cecilia, Frackelton Edward C, Garris Maria, Doran James, Romano Claudio, Catassi Carlo, Van Limbergen Johan, Guthery Stephen L, Denson Lee, Piccoli David, Silverberg Mark S, Stanley Charles A, Monos Dimitri, Wilson David C, Griffiths Anne, Grant Struan F A, Satsangi Jack, Polychronakos Constantin, Hakonarson Hakon
Abstract excerpt
Inflammatory bowel disease, including Crohn's disease (CD) and ulcerative colitis (UC), and type 1 diabetes (T1D) are autoimmune diseases that may share common susceptibility pathways. We examined known susceptibility loci for these diseases in a cohort of 1689 CD cases, 777 UC cases, 989 T1D cases and 6197 shared control subjects of European ancestry, who were genotyped by the Illumina HumanHap550 SNP arrays. We...
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