Article
Meta-analysis of published studies identified eight additional common susceptibility loci for Crohn's disease and ulcerative colitis.
Inflammatory bowel diseases - 1 Dec 2011
Umeno Junji, Asano Kouichi, Matsushita Tomonaga, Matsumoto Takayuki, Kiyohara Yutaka, Iida Mitsuo, Nakamura Yusuke, Kamatani Naoyuki, Kubo Michiaki
Abstract excerpt
BACKGROUND: Both ulcerative colitis (UC) and Crohn's disease (CD) have a complex etiology involving multiple genetic and environmental factors. Many genome-wide association studies (GWAS) and subsequent replication studies revealed that both diseases share some of the susceptibility loci; however, common genetic factors for both diseases are not fully elucidated. This study is aimed to identify the common genetic...
Topics
- Case-Control Studies
- Colitis, Ulcerative
- Crohn Disease
- Genetic Predisposition to Disease
- Genome, Human
- Genome-Wide Association Study
- Genotype
- Humans
- Polymorphism, Single Nucleotide
- Risk Factors