Article
Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis.
Inflammatory bowel diseases - 1 Sept 2011
Waterman Matti, Xu Wei, Stempak Joanne M, Milgrom Raquel, Bernstein Charles N, Griffiths Anne M, Greenberg Gordon R, Steinhart A Hillary, Silverberg Mark S
Abstract excerpt
BACKGROUND: A common genotypic basis for ulcerative colitis (UC) and Crohn's disease (CD) is implied by overlapping clinical characteristics, epidemiological studies, and association of genes with both UC and CD. We evaluated the overlap between CD and UC genetic loci stratified by pathogenetic pathways and by disease location. METHODS: The allele frequencies of six UC-associated and 34 CD-associated single...
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