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Article

PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.

PloS one - 1 Jan 2012

Glas Jürgen, Wagner Johanna, Seiderer Julia, Olszak Torsten, Wetzke Martin, Beigel Florian, Tillack Cornelia, Stallhofer Johannes, Friedrich Matthias, Steib Christian, Göke Burkhard, Ochsenkühn Thomas, Karbalai Nazanin, Diegelmann Julia, Czamara Darina, Brand Stephan

Abstract excerpt

BACKGROUND: Genome-wide association studies identified PTPN2 (protein tyrosine phosphatase, non-receptor type 2) as susceptibility gene for inflammatory bowel diseases (IBD). However, the exact role of PTPN2 in Crohn's disease (CD) and ulcerative colitis (UC) and its phenotypic effect are unclear...

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Source

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Identifiers

PMID: 22457781
DOI: 10.1371/journal.pone.0033682
PMCID: PMC3310077

Genes

PTPN2
EBP
NOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22457781-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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PTPN2 gene variants are associated with susceptibility to both Crohn's disease and ulcerative colitis supporting a common genetic disease background.PMID 22457781Read ↗

Associations between PTPN2 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: a meta-analysis.Semantic proximity Read ↗

Association between the PTPN2 gene and Crohn's disease: dissection of potential causal variants.Semantic proximity Read ↗

The Clinical Relevance of the IBD-Associated Variation within the Risk Gene Locus Encoding Protein Tyrosine Phosphatase Non-Receptor Type 2 in Patients of the Swiss IBD Cohort.Semantic proximity Read ↗

Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn’s disease and ulcerative colitisSemantic proximity Read ↗

PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population.Semantic proximity Read ↗

Distinct and overlapping genetic loci in Crohn's disease and ulcerative colitis: correlations with pathogenesis.Semantic proximity Read ↗

Association of PTPN22 gene (rs2488457) polymorphism with ulcerative colitis and high levels of PTPN22 mRNA in ulcerative colitis.Semantic proximity Read ↗

The presence of genetic risk variants within PTPN2 and PTPN22 is associated with intestinal microbiota alterations in Swiss IBD cohort patients.Semantic proximity Read ↗

Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.Semantic proximity Read ↗

PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.Semantic proximity Read ↗

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