Article
Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease.
Nature genetics - 9 Oct 2011
Rivas Manuel A, Beaudoin Mélissa, Gardet Agnes, Stevens Christine, Sharma Yashoda, Zhang Clarence K, Boucher Gabrielle, Ripke Stephan, Ellinghaus David, Burtt Noel, Fennell Tim, Kirby Andrew, Latiano Anna, Goyette Philippe, Green Todd, Halfvarson Jonas, Haritunians Talin, Korn Joshua M, Kuruvilla Finny, Lagacé Caroline, Neale Benjamin, Lo Ken Sin, Schumm Phil, Törkvist Leif, Dubinsky Marla C, Brant Steven R, Silverberg Mark S, Duerr Richard H, Altshuler David, Gabriel Stacey, Lettre Guillaume, Franke Andre, D'Amato Mauro, McGovern Dermot P B, Cho Judy H, Rioux John D, Xavier Ramnik J, Daly Mark J
Abstract excerpt
More than 1,000 susceptibility loci have been identified through genome-wide association studies (GWAS) of common variants; however, the specific genes and full allelic spectrum of causal variants underlying these findings have not yet been defined. Here we used pooled next-generation sequencing to study 56 genes from regions associated with Crohn's disease in 350 cases and 350 controls. Through follow-up...
Topics
- Case-Control Studies
- Cell Line
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Inflammatory Bowel Diseases