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Article

Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.

Nature genetics - 1 May 2007

Rioux John D, Xavier Ramnik J, Taylor Kent D, Silverberg Mark S, Goyette Philippe, Huett Alan, Green Todd, Kuballa Petric, Barmada M Michael, Datta Lisa Wu, Shugart Yin Yao, Griffiths Anne M, Targan Stephan R, Ippoliti Andrew F, Bernard Edmond-Jean, Mei Ling, Nicolae Dan L, Regueiro Miguel, Schumm L Philip, Steinhart A Hillary, Rotter Jerome I, Duerr Richard H, Cho Judy H, Daly Mark J, Brant Steven R

Abstract excerpt

We present a genome-wide association study of ileal Crohn disease and two independent replication studies that identify several new regions of association to Crohn disease. Specifically, in addition to the previously established CARD15 and IL23R associations, we identified strong and significantl...

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Identifiers

PMID: 17435756
DOI: 10.1038/ng2032
PMCID: PMC2757939

Genes

NCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17435756-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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