Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2.

doi:10.1053/j.gastro.2008.07.017

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Article

Genome-wide association analysis in sarcoidosis and Crohn's disease unravels a common susceptibility locus on 10p12.2.

Gastroenterology - 1 Oct 2008

Franke Andre, Fischer Annegret, Nothnagel Michael, Becker Christian, Grabe Nils, Till Andreas, Lu Tim, Müller-Quernheim Joachim, Wittig Michael, Hermann Alexander, Balschun Tobias, Hofmann Sylvia, Niemiec Regina, Schulz Sabrina, Hampe Jochen, Nikolaus Susanna, Nürnberg Peter, Krawczak Michael, Schürmann Manfred, Rosenstiel Philip, Nebel Almut, Schreiber Stefan

Abstract excerpt

BACKGROUND & AIMS: Crohn's disease (CD) and sarcoidosis (SA) are chronic inflammatory barrier diseases that share several clinical and immunological features, including the occurrence of granulomas. METHODS: A 100k genome-wide association study with 83,360 single-nucleotide polymorphisms (SNPs) was performed on 382 CD patients, 398 SA patients, and 394 control individuals. The 24 SNPs that were most strongly...

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PMID: 18723019
DOI: 10.1053/j.gastro.2008.07.017

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