Article
Possession of HLA class II DRB1*1303 associates with reduced viral loads in chronic HIV-1 clade C and B infection.
The Journal of infectious diseases - 15 Mar 2011
Julg Boris, Moodley Eshia S, Qi Ying, Ramduth Danni, Reddy Shabashini, Mncube Zenele, Gao Xiaojiang, Goulder Philip J, Detels Roger, Ndung'u Thumbi, Walker Bruce D, Carrington Mary
Abstract excerpt
BACKGROUND: The HLA class II molecules play a central role in the generation of human immunodeficiency virus (HIV)-specific CD4(+) T-helper cells, which are critical for the induction of cytotoxic CD8(+) T cell responses. However, little is known about the impact of HLA class II alleles on HIV disease progression. METHODS: In this study we investigated the effect of HLA class II alleles on HIV disease outcome and...
Topics
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- Cohort Studies
- Cytokines
- Female
- Gene Frequency
- Genotype
- HIV Infections
- HIV-1
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Male