Article
HIV-1 diversity versus HLA class I polymorphism.
Trends in immunology - 1 Jan 2005
Stephens Henry A F
Abstract excerpt
HIV-1 is rapidly diversifying in African, Asian and Caucasoid populations, which in parallel display extensive polymorphism of genes encoding class I human leukocyte antigens (HLA). Immune responses mediated by HLA class I molecules are imprinting mutations in HIV-1, which in turn affects HIV-1 diversity. Intra- and inter-ethnic studies have shown reproducible HLA class I allele, haplotype and supertype...
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