Article
Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
Journal of virology - 1 Apr 2007
Honeyborne Isobella, Prendergast Andrew, Pereyra Florencia, Leslie Alasdair, Crawford Hayley, Payne Rebecca, Reddy Shabashini, Bishop Karen, Moodley Eshia, Nair Kriebashnie, van der Stok Mary, McCarthy Noel, Rousseau Christine M, Addo Marylyn, Mullins James I, Brander Christian, Kiepiela Photini, Walker Bruce D, Goulder Philip J R
Abstract excerpt
To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three...
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