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Article

Association of HLA-DRB1-restricted CD4⁺ T cell responses with HIV immune control.

Nature medicine - 1 Jul 2013

Ranasinghe Srinika, Cutler Sam, Davis Isaiah, Lu Richard, Soghoian Damien Z, Qi Ying, Sidney John, Kranias Gregory, Flanders Michael D, Lindqvist Madelene, Kuhl Bjorn, Alter Galit, Deeks Steven G, Walker Bruce D, Gao Xiaojiang, Sette Alessandro, Carrington Mary, Streeck Hendrik

Abstract excerpt

The contribution of HLA class II-restricted CD4(+) T cell responses to HIV immune control is poorly defined. Here, we delineated previously uncharacterized peptide-DRB1 restrictions in functional assays and analyzed the host genetic effects of HLA-DRB1 alleles on HIV viremia in a large cohort of HIV controllers and progressors. We found distinct stratifications in the effect of HLA-DRB1 alleles on HIV viremia,...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 23793098
DOI: 10.1038/nm.3229
PMCID: PMC3974408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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