Article
HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.
Journal of virology - 1 Jan 2012
Kloverpris Henrik N, Stryhn Anette, Harndahl Mikkel, van der Stok Mary, Payne Rebecca P, Matthews Philippa C, Chen Fabian, Riddell Lynn, Walker Bruce D, Ndung'u Thumbi, Buus Søren, Goulder Philip
Abstract excerpt
The genetic polymorphism that has the greatest impact on immune control of human immunodeficiency virus (HIV) infection is expression of HLA-B*57. Understanding of the mechanism for this strong effect remains incomplete. HLA-B*57 alleles and the closely related HLA-B*5801 are often grouped together because of their similar peptide-binding motifs and HIV disease outcome associations. However, we show here that the...
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