Article
Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis.
PLoS pathogens - 1 Aug 2019
Claiborne Daniel T, Scully Eileen P, Palmer Christine D, Prince Jessica L, Macharia Gladys N, Kopycinski Jakub, Michelo Clive M, Wiener Howard W, Parker Rachel, Nganou-Makamdop Krystelle, Douek Daniel, Altfeld Marcus, Gilmour Jill, Price Matt A, Tang Jianming, Kilembe William, Allen Susan A, Hunter Eric
Abstract excerpt
Despite extensive research on the mechanisms of HLA-mediated immune control of HIV-1 pathogenesis, it is clear that much remains to be discovered, as exemplified by protective HLA alleles like HLA-B*81 which are associated with profound protection from CD4+ T cell decline without robust control of early plasma viremia. Here, we report on additional HLA class I (B*1401, B*57, B*5801, as well as B*81), and HLA...
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