Article
Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.
Journal of virology - 1 Aug 2010
Yindom Louis-Marie, Leligdowicz Aleksandra, Martin Maureen P, Gao Xiaojiang, Qi Ying, Zaman Syed M A, van der Loeff Maarten Schim, van Tienen Carla, Jaye Assan, Aveika Akum, Worwui Archibald, Diatta Mathurin, Vincent Tim, Whittle Hilton C, Rowland-Jones Sarah L, Walton Robert, Carrington Mary
Abstract excerpt
Overall, the time to AIDS after HIV-2 infection is longer than with HIV-1, and many individuals infected with HIV-2 virus remain healthy throughout their lives. Multiple HLA and KIR gene products have been implicated in the control of HIV-1, but the effect of variation at these loci on HIV-2 disease is unknown. We show here for the first time that HLA-B*1503 is associated significantly with poor prognosis after...
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