Article
APOE ε4 allele is associated with an increased risk of bulbar-onset amyotrophic lateral sclerosis in men.
European journal of neurology - 1 Aug 2011
Praline J, Blasco H, Vourc'h P, Garrigue M-A, Gordon P H, Camu W, Corcia P, Andres C R
Abstract excerpt
OBJECTIVE: Several association studies have identified possible susceptibility factors for sporadic amyotrophic lateral sclerosis (SALS). Studies on the APOE gene provided conflicting results, especially about the effect on bulbar onset. We assessed the possible role of APOE gene in a large cohort of patients with ALS and matched controls. METHODS: The APOE alleles were determined in 1482 patients with SALS and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.