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APOE ε4 Allele is Associated with Cognitive Impairment in Chinese Sporadic ALS: A Retrospective Cohort Study.

Biomedical and environmental sciences : BES - 20 May 2026

Sun Qiong Hua, Xuan Xuan, Du Yu Guo, Zhai Yu Cui, Ma Tie, Duan Feng, Xia Cui Qiao, Huang Xu Sheng, Huang Yong Hua, Wang Hong Fen

Abstract excerpt

Objective: To evaluate the effects of apolipoprotein E (APOE) genotype and serum APOE levels on cognitive and motor phenotypes in Chinese patients with sporadic amyotrophic lateral sclerosis (ALS). Methods: APOE genotypes were determined in 289 patients with sporadic ALS, and serum APOE levels were measured in a subset of 222 patients. Cognitive function was assessed using the Edinburgh Cognitive and Behavioural...

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PMID: 42205021
DOI: 10.3967/bes2026.038

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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