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Article

Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis.

Neurogenetics - 1 Dec 2004

Li Yi-Ju, Pericak-Vance Margaret A, Haines Jonathan L, Siddique Nailah, McKenna-Yasek Diane, Hung Wu-Yen, Sapp Peter, Allen Coy I, Chen Wenjie, Hosler Betsy, Saunders Ann M, Dellefave Lisa M, Brown Robert H, Siddique Teepu

Abstract excerpt

Apolipoprotein E (APOE) is a confirmed risk factor for Alzheimer disease. APOE is also involved in several other neurodegenerative disorders, including Parkinson disease and multiple sclerosis. Previous studies of amyotrophic lateral sclerosis (Lou Gehrig disease, ALS) have investigated the effect of APOE on the risk of developing ALS, age at onset, site of onset, and duration of the disease. The results have...

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Source

Identifiers

PMID: 15657798
DOI: 10.1007/s10048-004-0193-0

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Apolipoprotein E is associated with age at onset of amyotrophic lateral sclerosis.PMID 15657798Read ↗

Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis.Semantic proximity Read ↗

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Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Genetic Modifiers of Age at Onset for Amyotrophic Lateral Sclerosis: A Genome-Wide Association Study.Semantic proximity Read ↗

APOE: a potential marker of disease progression in ALS.Semantic proximity Read ↗

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.Semantic proximity Read ↗

Genome-wide analyses identify NEAT1 as genetic modifier of age at onset of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Apolipoprotein E controls the risk and age at onset of Parkinson disease.Semantic proximity Read ↗

APOE ε4 Allele is Associated with Cognitive Impairment in Chinese Sporadic ALS: A Retrospective Cohort Study.Semantic proximity Read ↗

APOE ε4 allele is associated with an increased risk of bulbar-onset amyotrophic lateral sclerosis in men.Semantic proximity Read ↗

Age at onset in two common neurodegenerative diseases is genetically controlled.Semantic proximity Read ↗

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