Article
Association of apolipoprotein E ε4 allele and amyotrophic lateral sclerosis in Chinese population.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Aug 2022
He Di, Shang Liang, Liu Qing, Shen Dongchao, Sun Xiaohan, Cai Zhengyi, Zhao Ximeng, Liu Liyang, Yang Xunzhe, Liu Mingsheng, Zhang Xue, Cui Liying
Abstract excerpt
Background: Amyotrophic lateral sclerosis (ALS) has a complex genetic origin, and how immune dysregulation may contribute to ALS etiology remain unclear. Given the roles played by apolipoprotein E (APOE) signaling in neuroinflammation and neurodegeneration, an improved knowledge of the association between APOE genotypes and ALS risk in Chinese population may help to understand the underlying etiology of the...
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