Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis.

doi:10.1016/j.jns.2008.06.025

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Article

Association of APOE with age at onset of sporadic amyotrophic lateral sclerosis.

Journal of the neurological sciences - 15 Oct 2008

Zetterberg Henrik, Jacobsson Johan, Rosengren Lars, Blennow Kaj, Andersen Peter M

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative syndrome with familial and sporadic forms. We conducted a study including 60 sporadic and 19 familial ALS patients, 206 reference patients with other neurological disorders and 1265 neurologically healthy controls to assess the Alzheimer-associated apolipoprotein E (APOE) epsilon4 gene variant as a possible risk factor for ALS. While no major influence of...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Amyotrophic Lateral Sclerosis
Apolipoprotein E4
Female
Gene Frequency
Genotype
Humans
Male
Middle Aged
Mutation
Superoxide Dismutase
Superoxide Dismutase-1
Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 18656208
DOI: 10.1016/j.jns.2008.06.025

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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