Article
Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis.
Neurogenetics - 1 Mar 1998
Siddique T, Pericak-Vance M A, Caliendo J, Hong S T, Hung W Y, Kaplan J, McKenna-Yasek D, Rimmler J B, Sapp P, Saunders A M, Scott W K, Siddique N, Haines J L, Brown R H
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neuro-degenerative disorder with both sporadic and familial forms. Approximately 20% of autosomal dominant ALS is caused by mutations in the Cu/Zn superoxide dismutase (SOD1) gene. The causes of the remaining forms of ALS are unknown. The apolipoprotein E (APOE) gene is a known genetic risk factor for Alzheimer disease (AD), another neuro-degenerative disease. The APOE-4...
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