Article
Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1990
Lechler R I, Sant A J, Braunstein N S, Sekaly R, Long E, Germain R N
Abstract excerpt
To aid in the identification of key residues responsible for the control of class II MHC beta-alpha dimer assembly and expression, a series of cotransfections of human plus mouse beta- and alpha-genes was performed. The resulting expression data were correlated with the sequences of the relevant...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- DNA Mutational Analysis
- Histocompatibility Antigens Class II
- Humans
- Immunologic Techniques
- L Cells
- Macromolecular Substances
- Mice
- Molecular Sequence Data
- Recombinant Proteins
- Structure-Activity Relationship
- Transfection