Article
Competition between MHC class I alleles for cell surface expression alters CTL responses to influenza A virus.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2002
Tourdot Sophie, Gould Keith G
Abstract excerpt
Mammalian cells express up to six different MHC class I alleles, many of which differ in terms of their interaction with components of the Ag presentation pathway and level of cell surface expression. However, it is often assumed in Ag presentation studies that class I alleles function independently of each other. We have compared cell surface expression levels and function of MHC class I molecules in F(1) hybrid...
Topics
- Alleles
- Animals
- Binding, Competitive
- Cell Membrane
- Crosses, Genetic
- Cytotoxicity, Immunologic
- Dose-Response Relationship, Immunologic
- Down-Regulation
- Female
- Gene Dosage
- Gene Expression Regulation
- H-2 Antigens
- Histocompatibility Antigen H-2D
- Histocompatibility Antigens Class I
- Influenza A virus
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL