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Article

Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation.

Immunity - 1 Oct 1995

Alam S M, Crispe I N, Gascoigne N R

Abstract excerpt

We report a detailed analysis of TCR V alpha and V beta chain expression on immature versus mature thymocytes of normal, TCR beta-transgenic, and TCR alpha-hemizygous mice. Chain pairing between TCR V alpha and V beta chains is random on immature thymocytes, but individual chain pairs are selected in mature thymocytes. This indicates that V alpha-V beta chain pairing preferences are determined during thymic...

Topics

Alleles
Animals
Antigens, CD
Cell Differentiation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Receptors, Antigen, T-Cell, alpha-beta
T-Lymphocytes
Thymus Gland
Up-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 7584136
DOI: 10.1016/1074-7613(95)90174-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7584136-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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