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Article

Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation.

Immunity - 1 Oct 1995

Alam S M, Crispe I N, Gascoigne N R

Abstract excerpt

We report a detailed analysis of TCR V alpha and V beta chain expression on immature versus mature thymocytes of normal, TCR beta-transgenic, and TCR alpha-hemizygous mice. Chain pairing between TCR V alpha and V beta chains is random on immature thymocytes, but individual chain pairs are selected in mature thymocytes. This indicates that V alpha-V beta chain pairing preferences are determined during thymic...

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Source

Identifiers

PMID: 7584136
DOI: 10.1016/1074-7613(95)90174-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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