Article
IGF-I gene variability is associated with an increased risk for AD.
Neurobiology of aging - 1 Mar 2011
Vargas Teo, Martinez-Garcia Ana, Antequera Desiree, Vilella Elisabet, Clarimon Jordi, Mateo Ignacio, Sanchez-Juan Pascual, Rodriguez-Rodriguez Eloy, Frank Ana, Rosich-Estrago Marcel, Lleo Alberto, Molina-Porcel Laura, Blesa Rafael, Gomez-Isla Teresa, Combarros Onofre, Bermejo-Pareja Felix, Valdivieso Fernando, Bullido Maria Jesus, Carro Eva
Abstract excerpt
Insulin-like growth factor I (IGF-I), a neuroprotective factor with a wide spectrum of actions in the adult brain, is involved in the pathogenesis of Alzheimer's disease (AD). Circulating levels of IGF-I change in AD patients and are implicated in the clearance of brain amyloid beta (Aβ) complexes. To investigate this hypothesis, we screened the IGF-I gene for various well known single nucleotide polymorphisms...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoproteins E
- DNA Mutational Analysis
- Female
- Gelsolin
- Gene Frequency
- Genotype