Decreased plasma β-amyloid in the Alzheimer's disease APP A673T variant carriers.

doi:10.1002/ana.24969

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Article

Decreased plasma β-amyloid in the Alzheimer's disease APP A673T variant carriers.

Annals of neurology - 1 Jul 2017

Martiskainen Henna, Herukka Sanna-Kaisa, Stančáková Alena, Paananen Jussi, Soininen Hilkka, Kuusisto Johanna, Laakso Markku, Hiltunen Mikko

Abstract excerpt

We investigated the association of Alzheimer's disease (AD)-related rare variants APP A673T and ABCA7 rs200538373-C with the levels of β-amyloid (Aβ) and parameters of metabolic and cardiovascular health in a population-based cohort of healthy middle-aged and elderly men. Carriers of protective APP A673T variant had, on average, 28% lower levels of Aβ40 and Aβ42 in plasma as compared to the controls and the...

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PMID: 28556232
DOI: 10.1002/ana.24969

Genes

APP
ABCA7

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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