Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease.

doi:10.1016/j.jocn.2013.09.028

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Article

Arg972 insulin receptor substrate-1 polymorphism and risk and severity of Alzheimer's disease.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia - 1 Jul 2014

Wang Wei, Yang Liang, Tan Liming, Wu Xiaomei, Jiang Bo, Shen Xiangmin

Abstract excerpt

We explored the association between the Arg972 insulin receptor substrate-1 (IRS1) polymorphism and the risk and severity of Alzheimer's disease (AD). We genotyped the Arg972 IRS1 (rs1801278) polymorphism in 1123 pairs of age, sex, body mass index, residence area and education level-matched Han Chinese AD patients and controls. AD severity was assessed with Mini-Mental State Examination (MMSE) scores. The AA...

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PMID: 24589556
DOI: 10.1016/j.jocn.2013.09.028

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IRS1

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