Article
Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study.
Neurology - 23 Jan 2018
Williams Dylan M, Karlsson Ida K, Pedersen Nancy L, Hägg Sara
Abstract excerpt
OBJECTIVE: To examine whether genetically predicted variation in circulating insulin-like growth factor 1 (IGF1) or its binding protein, IGFBP3, are associated with risk of Alzheimer disease (AD), using a mendelian randomization study design. METHODS: We first examined disease risk by genotypes of 9 insulin-like growth factor (IGF)-related single nucleotide polymorphisms (SNPs) using published summary genome-wide...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Case-Control Studies
- Female
- Forkhead Box Protein O3
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Insulin-Like Growth Factor Binding Protein 3