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Article

Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study.

Neurology - 23 Jan 2018

Williams Dylan M, Karlsson Ida K, Pedersen Nancy L, Hägg Sara

Abstract excerpt

OBJECTIVE: To examine whether genetically predicted variation in circulating insulin-like growth factor 1 (IGF1) or its binding protein, IGFBP3, are associated with risk of Alzheimer disease (AD), using a mendelian randomization study design. METHODS: We first examined disease risk by genotypes of 9 insulin-like growth factor (IGF)-related single nucleotide polymorphisms (SNPs) using published summary genome-wide...

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Identifiers

PMID: 29282328
DOI: 10.1212/WNL.0000000000004854
PMCID: PMC5798653

Genes

FOXO3
IGF1
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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