Article
Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.
Neurobiology of aging - 1 Jul 2014
Bamne Mikhil N, Demirci F Yesim, Berman Sarah, Snitz Beth E, Rosenthal Samantha L, Wang Xingbin, Lopez Oscar L, Kamboh M Ilyas
Abstract excerpt
A rare amyloid precursor protein gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer's disease and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations. We investigated this variant in 1674 late-onset Alzheimer's disease cases and 2644 elderly control subjects, all North American Whites (US...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Case-Control Studies
- Cognition Disorders
- Cohort Studies
- Female
- Genetic Association Studies
- Genotype