Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

doi:10.1016/j.neurobiolaging.2014.01.020

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Investigation of an amyloid precursor protein protective mutation (A673T) in a North American case-control sample of late-onset Alzheimer's disease.

Neurobiology of aging - 1 Jul 2014

Bamne Mikhil N, Demirci F Yesim, Berman Sarah, Snitz Beth E, Rosenthal Samantha L, Wang Xingbin, Lopez Oscar L, Kamboh M Ilyas

Abstract excerpt

A rare amyloid precursor protein gene variant, A673T (rs63750847) was recently reported to protect against Alzheimer's disease and age-related cognitive decline among Icelanders and the same rare variant was observed also in Finnish, Norwegian, and Swedish populations. We investigated this variant in 1674 late-onset Alzheimer's disease cases and 2644 elderly control subjects, all North American Whites (US...

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Identifiers

PMID: 24529499
DOI: 10.1016/j.neurobiolaging.2014.01.020
PMCID: PMC4009010

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