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Article

A polymorphism of the interleukin-1 beta gene at position +3953 influences progression and neuro-pathological hallmarks of Alzheimer's disease.

Neurobiology of aging - 1 Sept 2004

Licastro Federico, Veglia Fabrizio, Chiappelli Martina, Grimaldi Luigi Maria E, Masliah Eliezer

Abstract excerpt

Interleukin-1 (IL-1) gene polymorphisms are associated with an increased risk of Alzheimer's disease (AD) and it has been suggested that altered immune responses of the brain may play a role in the pathogenesis of the disease. Here we investigated whether IL-1beta polymorphisms affected neuro-pathological features and clinical status of AD patients with autopsy confirmed diagnosis of the disease. AD patients...

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Identifiers

PMID: 15212826
DOI: 10.1016/j.neurobiolaging.2003.11.002

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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