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Article

Two novel human NUMB isoforms provide a potential link between development and cancer

1 Dec 2010

Abstract excerpt

We previously identified four functionally distinct human NUMB isoforms. Here, we report the identification of two additional isoforms and propose a link between the expression of these isoforms and cancer. These novel isoforms, NUMB5 and NUMB6, lack exon 10 and are expressed in cells known for polarity and migratory behavior, such as human amniotic fluid cells, glioblastoma and metastatic tumor cells. RT-PCR and...

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PMID: 21122105
DOI: 10.1186/1749-8104-5-31

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