Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.

doi:10.1016/s0896-6273(00)80279-2

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Article

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.

Neuron - 1 Jul 1996

Zhong W, Feder J N, Jiang M M, Jan L Y, Jan Y N

Abstract excerpt

During Drosophila neurogenesis, differential segregation of Numb is necessary for daughter cells of asymmetric divisions to adopt distinct fates, at least partly by biasing the Notch-mediated cell-cell interaction. We have isolated a highly conserved mammalian homolog of Drosophila numb, m-numb....

Topics

Amino Acid Sequence
Animals
Cell Division
Cell Membrane
Cerebral Cortex
Drosophila
Drosophila Proteins
Embryo, Mammalian
Embryo, Nonmammalian
Embryonic and Fetal Development
Juvenile Hormones
Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Molecular Sequence Data

Mutation

Neurons

Rats

Receptors, Cell Surface

Source

Open in PubMed

Identifiers

PMID: 8755477
DOI: 10.1016/s0896-6273(00)80279-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8755477-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.PMID 8755477Read ↗

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Numb antagonizes Notch signaling to specify sibling neuron cell fates.Semantic proximity Read ↗

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Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors.Semantic proximity Read ↗

Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.Semantic proximity Read ↗

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