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Article

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.

Neuron - 1 Jul 1996

Zhong W, Feder J N, Jiang M M, Jan L Y, Jan Y N

Abstract excerpt

During Drosophila neurogenesis, differential segregation of Numb is necessary for daughter cells of asymmetric divisions to adopt distinct fates, at least partly by biasing the Notch-mediated cell-cell interaction. We have isolated a highly conserved mammalian homolog of Drosophila numb, m-numb. During mouse cortical neurogenesis, m-Numb is asymmetrically localized to the apical membrane of dividing ventricular...

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PMID: 8755477
DOI: 10.1016/s0896-6273(00)80279-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.PMID 8755477Read ↗

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Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.Semantic proximity Read ↗

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