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The Multitasker Protein: A Look at the Multiple Capabilities of NUMB

15 Jan 2023

Abstract excerpt

, is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent and has multiple functions, including endocytosis and serving as an adaptor in various cellular pathways such as NOTCH, Hedgehog, and the P53-MDM2...

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PMID: 36672267
DOI: 10.3390/cells12020333

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The Multitasker Protein: A Look at the Multiple Capabilities of NUMBPMID 36672267Read ↗

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Numb regulates post-endocytic trafficking and degradation of Notch1.Semantic proximity Read ↗

Going vertical: functional role and working principles of the protein Inscuteable in asymmetric cell divisions.Semantic proximity Read ↗

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cellsSemantic proximity Read ↗

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The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.Semantic proximity Read ↗

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