Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.

doi:10.1242/dev.124.10.1887

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Article

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.

Development (Cambridge, England) - 1 May 1997

Zhong W, Jiang M M, Weinmaster G, Jan L Y, Jan Y N

Abstract excerpt

During Drosophila neurogenesis, asymmetric cell divisions are achieved by differential segregation of Numb (d-Numb) into one of the daughter cells to cause a bias in the Notch mediated cell-cell interaction. We have isolated a second mammalian gene with significant sequence similarity to d-numb,...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cerebral Cortex
Cloning, Molecular
Cytoplasm
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Genes
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Juvenile Hormones

Membrane Proteins

Mice

Models, Neurological

Molecular Sequence Data

Morphogenesis

Mutation

Source

Open in PubMed

Identifiers

PMID: 9169836
DOI: 10.1242/dev.124.10.1887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9169836-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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