Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase Activity

2 May 2012

Abstract excerpt

Glioblastoma contains a hierarchy of stem-like cancer cells, but how this hierarchy is established is unclear. Here, we show that asymmetric Numb localization specifies glioblastoma stem-like cell (GSC) fate in a manner that does not require Notch inhibition. Numb is asymmetrically localized to CD133-hi GSCs. The predominant Numb isoform, Numb4, decreases Notch and promotes a CD133-hi, radial glial-like...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation
Share to Neurogenesis and neuroplasticity mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22553175
DOI: 10.1002/stem.1120

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase ActivityPMID 22553175Read ↗

LNX1 Modulates Notch1 Signaling to Promote Expansion of the Glioma Stem Cell Population During Temozolomide Therapy in GlioblastomaSemantic proximity Read ↗

Molecular Pathways and Genomic Landscape of Glioblastoma Stem Cells: Opportunities for Targeted TherapySemantic proximity Read ↗

Human <i>Brat</i> Ortholog <i>TRIM3</i> Is a Tumor Suppressor That Regulates Asymmetric Cell Division in GlioblastomaSemantic proximity Read ↗

Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration.Semantic proximity Read ↗

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancersSemantic proximity Read ↗

SLFN11 Negatively Regulates Noncanonical NFκB Signaling to Promote Glioblastoma ProgressionSemantic proximity Read ↗

TRIM 8 regulates stemness in glioblastoma through PIAS 3‐ STAT 3Semantic proximity Read ↗

The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMBSemantic proximity Read ↗

S100A4 Is a Biomarker and Regulator of Glioma Stem Cells That Is Critical for Mesenchymal Transition in GlioblastomaSemantic proximity Read ↗

Morphoregulatory ADD3 underlies glioblastoma growth and formation of tumor–tumor connectionsSemantic proximity Read ↗

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators.Semantic proximity Read ↗

A Novel Role of BIRC3 in Stemness Reprogramming of GlioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.