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Article

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.

Breast cancer research and treatment - 1 Jul 2010

Rennstam Karin, McMichael Nicole, Berglund Pontus, Honeth Gabriella, Hegardt Cecilia, Rydén Lisa, Luts Lena, Bendahl Pär-Ola, Hedenfalk Ingrid

Abstract excerpt

Decreased expression of Numb, resulting in activation of the proto-oncogene Notch1 and reduction in the tumor suppressor p53, has been demonstrated in mammary carcinomas. The aim of this study was to investigate the relationship between Numb protein expression and clinicopathological characterist...

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Source

Identifiers

PMID: 19795205
DOI: 10.1007/s10549-009-0568-x

Genes

BRCA1
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19795205-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.PMID 19795205Read ↗

Pre‐clinical validation of a selective anti‐cancer stem cell therapy for Numb‐deficient human breast cancersSemantic proximity Read ↗

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling.Semantic proximity Read ↗

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cellsSemantic proximity Read ↗

Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancerSemantic proximity Read ↗

The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB LevelsSemantic proximity Read ↗

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase ActivitySemantic proximity Read ↗

BCL6 and the Notch pathway: a signaling axis leading to a novel druggable biotarget in triple negative breast cancerSemantic proximity Read ↗

Two novel human NUMB isoforms provide a potential link between development and cancerSemantic proximity Read ↗

Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis.Semantic proximity Read ↗

Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitrySemantic proximity Read ↗

Alterations of the Notch pathway in lung cancer.Semantic proximity Read ↗

Numb−/low Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog SignalingSemantic proximity Read ↗

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