Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.

Developmental neuroscience - 1 Jan 2006

Toriya Masako, Tokunaga Akinori, Sawamoto Kazunobu, Nakao Keiko, Okano Hideyuki

Abstract excerpt

Mammalian Numb (mNumb) has multiple functions and plays important roles in the regulation of neural development, including maintenance of neural progenitor cells and promotion of neuronal differentiation in the central nervous system (CNS). However, the molecular bases underlying the distinct functions of Numb have not yet been elucidated. mNumb, which has four splicing isoforms, can be divided into two types...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Animals, Genetically Modified

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Biological Assay

Share to Cell Lineage

Share to Juvenile Hormones

Share to Receptors, Notch

Share to Stem Cells

Source

Identifiers

PMID: 16508311
DOI: 10.1159/000090760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.PMID 16508311Read ↗

The enigma of the numb-Notch relationship during mammalian embryogenesis.Semantic proximity Read ↗

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.Semantic proximity Read ↗

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.Semantic proximity Read ↗

Mouse numb is an essential gene involved in cortical neurogenesis.Semantic proximity Read ↗

Progenitor cell maintenance requires numb and numblike during mouse neurogenesis.Semantic proximity Read ↗

Numb Suppresses Notch-Dependent Activation of Enhancer of split during Lateral Inhibition in the Drosophila Embryonic Nervous System.Semantic proximity Read ↗

dp53 Restrains ectopic neural stem cell formation in the Drosophila brain in a non-apoptotic mechanism involving Archipelago and cyclin E.Semantic proximity Read ↗

Numb modulates intestinal epithelial cells toward goblet cell phenotype by inhibiting the Notch signaling pathway.Semantic proximity Read ↗

Mammalian numb-interacting protein 1/dual oxidase maturation factor 1 directs neuronal fate in stem cells.Semantic proximity Read ↗

Two novel human NUMB isoforms provide a potential link between development and cancerSemantic proximity Read ↗

bHLH-O proteins are crucial for Drosophila neuroblast self-renewal and mediate Notch-induced overproliferation.Semantic proximity Read ↗

Numb Regulates Glioma Stem Cell Fate and Growth by Altering Epidermal Growth Factor Receptor and Skp1-Cullin-F-Box Ubiquitin Ligase ActivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.