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Article

Numb modulates intestinal epithelial cells toward goblet cell phenotype by inhibiting the Notch signaling pathway.

Experimental cell research - 1 Jul 2011

Yang Yongtao, Zhu Rong, Bai Jianying, Zhang Xin, Tian Yin, Li Xiaohuan, Peng Zhihong, He Yonghong, Chen Lei, Ji Qing, Chen Wensheng, Fang Dianchun, Wang Rongquan

Abstract excerpt

Numb was originally identified as an important cell fate determinant that is asymmetrically inherited during mitosis and controls the fate of sibling cells by inhibiting the Notch signaling pathway in neural tissue. The small intestinal epithelium originates from the division of stem cells that reside in the crypt, which further differentiate into goblet cells, absorptive cells, paneth cells, and enteroendocrine...

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Source

Identifiers

PMID: 21557937
DOI: 10.1016/j.yexcr.2011.04.008

Genes

MUC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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