Article

Pan tissue analysis of human <i>NUMB</i> alternative splicing

2023-09-28

Abstract excerpt

Alternative splicing (AS) of pre-mRNA generates multiple protein isoforms from a single gene. It is developmentally regulated and mis-regulation is associated with many diseases. Previous studies that examined AS of the cell fate determinant NUMB demonstrated that it undergoes a regulated switch in the inclusion of protein coding exons 3 and 9 during rodent development and the differentiation of human cell lines....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f4596b1e-58ff-5f7e-93f3-f4fec4eff371
DOI: 10.1101/2023.09.26.559629

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pan tissue analysis of human <i>NUMB</i> alternative splicingDOI 10.1101/2023.09.26.559629Read

Alternative splicing of NUMB correlates with tumor immune evasion and metabolic adaptationSemantic proximity Read

Two novel human NUMB isoforms provide a potential link between development and cancerSemantic proximity Read

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks.Semantic proximity Read

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networksSemantic proximity Read

Distinct functions of human numb isoforms revealed by misexpression in the neural stem cell lineage in the Drosophila larval brain.Semantic proximity Read

The Multitasker Protein: A Look at the Multiple Capabilities of NUMBSemantic proximity Read

Numb protein expression correlates with a basal-like phenotype and cancer stem cell markers in primary breast cancer.Semantic proximity Read

NUMB dysfunction defines a novel mechanism underlying hyperuricemia and goutSemantic proximity Read

Comprehensive analysis of NuMA variation in breast cancer.Semantic proximity Read

Tumor suppressor properties of the splicing regulatory factor RBM10.Semantic proximity Read

Role of NuMA1 in breast cancer stem cells with implications for combination therapy of PIM1 and autophagy inhibition in triple negative breast cancerSemantic proximity Read

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis.Semantic proximity Read