Article

Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry

2024-08-28

Abstract excerpt

<h4>ABSTRACT</h4> Bladder cancer (BCa) is one of the most challenging and costly cancers to treat, yet little progress has been made on the development of predictive biomarkers and targeted therapies. Here, we uncover a critical function of Numb as a tumor suppressor in the bladder, identifying loss of Numb expression as a causal alteration in BCa that underlies biological aggressiveness and disease progression....

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Literature Corpus work: 7a52abc5-b8a6-5cd0-97aa-f3c39240fdb9
DOI: 10.1101/2024.08.27.609735

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