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Article

Mouse numb is an essential gene involved in cortical neurogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2000

Zhong W, Jiang M M, Schonemann M D, Meneses J J, Pedersen R A, Jan L Y, Jan Y N

Abstract excerpt

During neurogenesis of the mammalian neocortex, neural progenitor cells divide to generate daughter cells that either become neurons or remain as progenitor cells. The mouse numb (m-numb) gene encodes a membrane-associated protein that is asymmetrically localized to the apical cell membrane of dividing cortical progenitor cells and may be segregated to only the apical daughter cell that has been suggested to...

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Identifiers

PMID: 10841580
DOI: 10.1073/pnas.97.12.6844
PMCID: PMC18761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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